Tuesday, December 22, 2020

Suspicions Grow That Nanoparticles in Pfizer's Covid Vaccine (Injectible RNA Therapy) May Trigger Deadly Anaphylactic Reactions

Yup, suspicions grow.... You really should read the entire article from Science

Severe allergy-like reactions in at least eight people who received the COVID-19 vaccine produced by Pfizer and BioNTech over the past 2 weeks may be due to a compound in the packaging of the messenger RNA (mRNA) that forms the vaccine’s main ingredient, scientists say. A similar mRNA vaccine developed by Moderna, which was authorized for emergency use in the United States on Friday, also contains the compound, polyethylene glycol (PEG).

PEG has never been used before in an approved (correction, authorized for emergency use)  vaccine, but it is found in many drugs that have occasionally triggered anaphylaxis—a potentially life-threatening reaction that can cause rashes, a plummeting blood pressure, shortness of breath, and a fast heartbeat. Some allergists and immunologists believe a small number of people previously exposed to PEG may have high levels of antibodies against PEG, putting them at risk of an anaphylactic reaction to the vaccine.

Digression and Trip Down Memory Lane

Let's talk about PEG- Polyethylene Glycol-  Anti freeze? In my world it is very much an anti freeze. It has similar properties And pathetically, yes, it is included in some food and beauty products. And laxatives. That cause behavioural problems in children. It is a petroleum product. 

One could liken it to Rockefeller's snake oil? 

And like every snake oil salesman, he had a cure-all tonic to hock. He called it Rock Oil and charged $25 a bottle for it, equivalent at the time to 2 months’ salary for the average American worker. Claiming it could cure all but the most terminal cancers, there were always desperate souls in every town who could be duped into buying a bottle.

As near as anyone can tell, “Rock Oil” was in fact just a mixture of Laxative & Petroleum OIL and had no effect whatsoever on the cancer of the poor townsfolk he conned into buying it. But “Dr. Bill” didn’t have to worry about the consequences when his customers discovered they’d been had; he never stayed in any one place for very long.

 We've really not gone to far down the road from John D Rockefeller's snake oil salesman Daddy and Rockefeller's Medicine Men I read the book some years back. Had it linked here twice. The more things change.. the more they are exactly the same 

 Back to Science 

"Others are skeptical of the link. Still, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) was concerned enough to convene several meetings last week to discuss the allergic reactions with representatives of Pfizer and Moderna, independent scientists and physicians, and the Food and Drug Administration (FDA).

NIAID is also setting up a study in collaboration with FDA to analyze the response to the vaccine in people who have high levels of anti-PEG antibodies or have experienced severe allergic responses to drugs or vaccines before. “Until we know there is truly a PEG story, we need to be very careful in talking about that as a done deal,” says Alkis Togias, branch chief of allergy, asthma, and airway biology at NIAID.

Pfizer, too, says it is “actively seeking follow-up.” A statement emailed to Science noted it already recommends that “appropriate medical treatment and supervision should always be readily available” in case a vaccinee develops anaphylaxis.

Anaphylactic reactions can occur with any vaccine, but are usually extremely rare—about one per 1 million doses. As of 19 December, the United States had seen six cases of anaphylaxis among 272,001 people who received the COVID-19 vaccine, (that's a statistically significant and problematic, deadly reaction) according to a recent presentation by Thomas Clark of the U.S. Centers for Disease Control and Prevention (CDC); the United Kingdom has recorded two. Because the Pfizer and Moderna mRNA vaccines use a new platform, the reactions call for careful scrutiny, says Elizabeth Phillips, a drug hypersensitivity researcher at Vanderbilt University Medical Center who attended an NIAID meeting on 16 December. “This is new.” 

News reports about the allergic reactions have already created anxiety. “Patients with severe allergies in the US are getting nervous about the possibility that they may not be able to get vaccinated, at least with those two vaccines,” Togias wrote in an invitation to meeting participants. “Allergies in general are so common in the population that this could create a resistance against the vaccines in the population,” adds Janos Szebeni, an immunologist at Semmelweis University in Budapest, Hungary, who has long studied hypersensitivity reactions to PEG and who also attended the 16 December gathering.

Scientists who believe PEG may be the culprit stress that vaccination should continue. “We need to get vaccinated,” Phillips says. “We need to try and curtail this pandemic.” But more data are urgently needed, she adds: “These next couple of weeks in the U.S. are going to be extremely important for defining what to do next.”

The two vaccines both contain mRNA wrapped in lipid nanoparticles (LNPs) that help carry it to human cells but also act as an adjuvant, a vaccine ingredient that bolsters the immune response. The LNPs are “PEGylated”—chemically attached to PEG molecules that cover the outside of the particles and increase their stability and life span.

PEGs are also used in everyday products such as toothpaste and shampoo as thickeners, solvents, softeners, and moisture carriers, and they’ve been used as a laxative for decades. An increasing number of biopharmaceuticals include PEGylated compounds as well.

PEGs were long thought to be biologically inert, but a growing body of evidence suggests they are not. As much as 72% of people have at least some antibodies against PEGs, according to a 2016 study led by Samuel Lai, a pharmaco-engineer at the University of North Carolina, Chapel Hill, presumably as a result of exposure to cosmetics and pharmaceuticals. About 7% have a level that may be high enough to predispose them to anaphylactic reactions, he found. Other studies have also found antibodies against PEG, but at lower levels.

“Some companies have dropped PEGylated products from their pipeline as a result,” Lai says. But he notes that the safety record of many PEGylated drugs has persuaded others that “concerns about anti-PEG antibodies are overstated.”

Szebeni says the mechanism behind PEG-conjugated anaphylaxis is relatively unknown because it does not involve immunoglobulin E (IgE), the antibody type that causes classical allergic reactions. (That’s why he prefers to call them “anaphylactoid” reactions.) Instead, PEG triggers two other classes of antibodies, immunoglobulin M (IgM) and immunoglobulin G (IgG), involved in a branch of the body’s innate immunity called the complement system, which Szebeni has spent decades studying in a pig model he developed.

In 1999, while working at the Walter Reed Army Institute of Research, Szebeni described a new type of drug-induced reaction he dubbed complement activation-related pseudoallergy (CARPA), a nonspecific immune response to nanoparticle-based medicines, often PEGylated, that are mistakenly recognized by the immune system as viruses.

Szebeni believes CARPA explains the severe anaphylactoid reactions some PEGylated drugs are occasionally known to cause, including cancer blockbuster Doxil. A team assembled by Bruce Sullenger, a surgeon at Duke University, experienced similar issues with an experimental anticoagulant containing PEGylated RNA. The team had to halt a phase III trial in 2014 after about 0.6% of 1600 people who received the drug had severe allergic responses and one participant died. “That stopped the trial,” Sullenger says. The team found that every participant with an anaphylaxis had high levels of anti-PEG IgG. But some with no adverse reaction had high levels as well, Sullenger adds. “So, it is not sufficient to just have these antibodies.”

At the NIAID meeting, several attendees stressed that PEGylated nanoparticles may cause problems through a mechanism other than CARPA. Just last month, Phillips and scientists at FDA and other institutions published a paper showing patients who suffered an anaphylactic reaction to PEGylated drugs did have IgE antibodies to PEG after all, suggesting those may be involved, rather than IgG and IgM.

Other scientists, meanwhile, are not convinced PEG is involved at all. “There is a lot of exaggeration when it comes to the risk of PEGs and CARPA,” says Moein Moghimi, a nanomedicine researcher at Newcastle University who suspects a more conventional mechanism is causing the reactions. “You are technically delivering an adjuvant at the injection site to excite the local immune system. It happens that some people get too much excitement, because they have a relatively high number of local immune cells.”

And you'll have to read the rest at the link provided to Science.

 Related: 

If you read the Science article entirely you will remember an individual named in this previous report.... Covid Vaccine Guinea Pigs... Unprecedented, Novel, Vaccine Technology. Eliciting an ADE & Increasing YOUR Risk of More Severe Disease. Check the Salon article.

 Additional related information:

8 comments:

  1. Sounds like any ethical Media would call for an immediate halt to the "Rollout" what with the new CDC statistics and your post above. It's a "no brainer", right?

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  2. Polyethylene glycol is a blanket term for any of thousands of molecules with the same basic structure. They're usually designated as PEG-X, X referring to the molecular weight.

    The "antifreeze" designation imho is a dubious buzzword, as any number of substances are used to depress the freezing point of water, most of these substances being similar to sugar or alcohol. Though, few of them are as "harmless" as sugar or alcohol. Automotive antifreeze, or ethylene glycol, poses a very specific risk which is quite different that PEG. People with modest technical knowledge know this and roll their eyes when they see people making the comparison. I know this, because I was once one of those people.

    Having said that, I think the abundance of evidence proves these substances do not belong in a living body in any shape or form. Laxatives are the most shocking example, as this involves drinking a massive quantity of straight PEG 3350. My mother's doctor has done numerous things over the years to prove to me she can't be trusted, and prescribing this garbage is just one.

    I used to use a different but similar chemical, propylene glycol, in my e-cigarette liquid. The cigarette occasionally dripped on to my thumb and t-shirt, and after a couple of years I developed dermatitis on my thumb and chest. Luckily it didn't take me long to make the connection, but it's taken a long time for the inflammation to subside. Nothing I tried made it calm down, and I've tried antibiotics, antifungals, steroid creams, colloidal silver, and many other things. The only thing which seemed to help in the least was a sulfur compound I stumbled across as an old remedy for cyanide poisoning and skin conditions. It's still noticeable on my skin.

    I think propylene glycol is probably more insidious because it's in more foods, medications, and cosmetics. It's a skin sensitizer, and I assume it sensitizes lungs and internal organs as well, wreaking untold havoc on the body's systems.

    I sometimes wonder if the threat of mandatory vaccination is just a red herring. As long as people are worried about being forcibly vaccinated, they're not paying much attention to what this operation is costing. Forced mass-vaccination or not, in the end the taxpayers will have still footed the bill for billions of doses, R&D and distribution. The end result will still be a whole new market treating those "volunteers" sickened by the vaccine.

    I just want out. I was fortunate to live abroad for some time and to witness from a fresh perspective the mass-mental illness of a sick, unhappy, dis-empowered society on my return. This is no way to live, unfortunately most people just can't see that because they've never stepped outside of the madness. They don't know all they have to do is say no on a personal level and refuse to buy the garbage and play the game, refuse to live in the mental and emotional confines of pop-culture and all the sick role models it hawks as worth aspiring to, and all the dissatisfaction they experience from the meaninglessness it all entails.

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  3. Hi wafflestaffel:

    I understand your take on my choice of words, and appreciate the clarification. That said, let's get to what we agree on

    "Having said that, I think the abundance of evidence proves these substances do not belong in a living body in any shape or form."

    It appears the body itself understand these substances don't belong within- If my understanding is correct it seems the body tries to fight these toxic invaders off.. by generating anti bodies.

    "PEGs were long thought to be biologically inert, but a growing body of evidence suggests they are not. As much as 72% of people have at least some antibodies against PEGs,"


    I love the use of "thought to be inert". One would think the presence of antibodies against PEG would have one thinking otherwise?

    I just want out. I was fortunate to live abroad for some time and to witness from a fresh perspective the mass-mental illness of a sick, unhappy, dis-empowered society on my return. This is no way to live, unfortunately most people just can't see that because they've never stepped outside of the madness. They don't know all they have to do is say no on a personal level and refuse to buy the garbage and play the game, refuse to live in the mental and emotional confines of pop-culture and all the sick role models it hawks as worth aspiring to, and all the dissatisfaction they experience from the meaninglessness it all entails.

    This I understand well. The mass mental illness of a dis eased dis empowered society. It is no way to live. There are ways to step outside of the toxic unreality... the first would be shutting off the tell a vision. Toss the smart (pain) phone. Disconnecting from toxic social media. Tend a garden. Choose your food wisely. One's mind can change quickly when it's not be continuously exposed to the toxicity of this dysfunctional society


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    Replies
    1. Thanks Penny. Just to clarify, I wasn't referring to your use of the word specifically, just in general. That's just me being a pedantic big mouth.

      I swear I weren't criticizing you!

      Delete
  4. WaffleStaffel said: "My mother's doctor has done numerous things over the years to prove to me she can't be trusted, and prescribing this garbage is just one."

    I agree heartily about not trusting doctors. I'm old, and my past diagnoses and treatments by medical professionals were guess-work at best and, as I continue to age and am aware of gradually, bit by tiny bit, deteriorating mentally and physically, I feel literal fear of ending up back in their hands. I would rather die than consult a medical professional -- except my pharmacist who is very good at helping me mull over and experiment with dietary supplements.

    "Choose your food wisely." Excellent advice. And said in the right place because Penny has always advocated the same.

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    Replies
    1. You're absolutely right, yaya. Guess work at best, following big-pharma protocol at worst. My mother's problems began when her new, much younger doctor switched her blood pressure meds for no explicable reason. I am of the firm belief that this led to a series of undetected heart attacks. It made her so light headed she couldn't even walk from the living room to the kitchen. Communication was so bad, and the doctor's office so obstinate about doing anything, we had to switch her back to the other med on our own.

      My mother saw her father and his countertop filled with pill bottles and she talked about how crazy it was and how there couldn't possibly be any good reason for it, yet she opened her eyes one day and saw the same thing on her countertop.

      We've worked to get her down to just 2 drugs, thyroid and blood pressure. I'm sure we could eliminate those with more work, but I see diminishing returns at this point.

      You're right, and I think the majority of us could do without "routine" doctor visits. With effort and good choices the deterioration doesn't have to be inevitable.

      Absolutely correct, our diet is bad to begin with, but the food supply has become so much more poisonous even in the last 10-20 years it's essential to evaluate what we put in our kitchen.

      Delete
  5. Your mother is lucky to have you, WaffleStaffel. I'd be willing to bet that the reason your mother's blood pressure meds were changed was simply because the doctor had received a visit (and no doubt a perk or two) from a pharma saleserson who said, "This is the latest and best thing. Try it out. Your patients will love you for it."

    ReplyDelete

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