Tuesday, June 15, 2021

Human Cells CAN write RNA sequences into DNA, Study Shows: mRNA Operating System and Cancer

Who among you recall this? modeRNA

Our Operating System

Recognizing the broad potential of mRNA science, we set out to create an mRNA technology platform that functions very much like an operating system on a computer. It is designed so that it can plug and play interchangeably with different programs. In our case, the "program” or “app” is our mRNA drug - the unique mRNA sequence that codes for a protein.


The article below should be kept for future reference:

For the first time, scientists have found evidence that polymerase theta can write RNA segments back into DNA.

 According to the researchers, these findings potentially challenge a central dogma in biology and could have wide implications.

Cells contain polymerases that duplicate DNA into another set that goes into a newly formed cell. These also build RNA messages so they can be read more efficiently into proteins. Polymerases were thought to only work in one direction – DNA into DNA or RNA. This prevents RNA messages from being rewritten back into the master recipe book of genomic DNA. However, the study sheds new light on this process.
“This work opens the door to many other studies that will help us understand the significance of having a mechanism for converting RNA messages into DNA in our own cells,said Dr Richard Pomerantz, one of the lead researchers. “The reality that a human polymerase can do this with high efficiency, raises many questions.”

For example, this finding suggests that RNA messages can be used as templates for repairing or re-writing genomic DNA.

The team started by investigating polymerase theta. This repairs DNA, but is error-prone and produces mutations. The researchers therefore noticed that some of polymerase theta’s “bad” qualities were ones it shared with another cellular machine – reverse transcriptase. Like polymerase theta, HIV reverse transcriptase acts as a DNA polymerase, but can also bind RNA and read RNA back into a DNA strand.

In a series of experiments, the researchers tested polymerase theta against the reverse transcriptase from HIV. They showed that polymerase theta was capable of converting RNA messages into DNA, which it did as well as HIV reverse transcriptase and that it did a better job than when duplicating DNA to DNA. Polymerase theta was also more efficient and introduced fewer errors when using an RNA template to write new DNA messages, suggesting that this function could be its primary purpose in the cell.

The group used X-ray crystallography to define the structure and found that this molecule was able to change shape in order to accommodate the more bulky RNA molecule, which is unique among polymerases.

“Our research suggests that polymerase theta’s main function is to act as a reverse transcriptase,” said Pomerantz. “In healthy cells, the purpose of this molecule may be toward RNA-mediated DNA repair. In unhealthy cells, such as cancer cells, polymerase theta is highly expressed and promotes cancer cell growth and drug resistance. It will be exciting to further understand how polymerase theta’s activity on RNA contributes to DNA repair and cancer-cell proliferation.
Further reading

Advances Science

I'm certainly not naive enough to believe this technology would be used for the happiness/benefit of humankind. In fact it appears as if it has the possibility to promote cancer growth and drug resistance. Exciting to understand how RNA contributes to DNA repair and cancer cell proliferation????

 Recall this previous report? April 2021

Most people think of cancer as a disease of disorderly DNA. Changes, or mutations, in the sequence of DNA alter the function of the proteins made from that DNA, leading to uncontrolled cell division.

But between DNA and proteins is another layer of information, called messenger RNA (mRNA), which serves as a crucial link between the two. New research suggests that mRNA itself may carry cancer-causing changes.

This makes me feel very uncomfortable. I'm seriously concerned about the mRNA vaccines creating a massive cancer epidemic. Worse then we already have now.  Understanding cancer is the big money maker for the pharmaceutical industry.

11 comments:

  1. please share this.. I mean 'follow the science' as the Greeda Thunberg suggests- though we know she follows the money. As do the pharmaceutical companies.
    Seriously tinkering with the rna/dna is in my opinion an abomination.

    ReplyDelete
  2. FYI:
    I'm reading Christopher Lasch's book
    Culture of Narcissism: American Life In An Age Of Diminishing
    Prophetic


    https://www.goodreads.com/book/show/38212112-the-culture-of-narcissism

    When The Culture of Narcissism was first published in 1979, Christopher Lasch was hailed as a “biblical prophet” (Time). Lasch’s identification of narcissism as not only an individual ailment but also a burgeoning social epidemic was groundbreaking. His diagnosis of American culture is even more relevant today, predicting the limitless expansion of the anxious and grasping ...more

    The updated intro is a bit lame (who gives a shite about Trump when Biden is a bigger idiot) it's the decades old work of Lasch's that is very, very good

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  3. "Robert Reich: In 1979, when 33 year-old Donald Trump was building Trump Tower"
    The elite yes-men never pass up an opportunity to advertise their allegiance by flashing their gang signs.

    ReplyDelete
    Replies
    1. Yes, I see in the comments there is a Trump basher who had to make the book about Trump- it isn't.
      It isn't at all.
      I read through a few more of the comments to see which connected most with my view.. can't say at this time
      When I'm done the book, I'll write on here or see which one already there more closely aligns with my views on the book

      Delete
  4. ...and the irony of hailing the writer as a "biblical prophet". They serve you the truth in a poisoned chalice.

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  5. You're right, Penny. It seems one (of the many) goals of this operation was to throw open the doors to mRNA technology, which has so far ranged from abysmal failure to wrought with unintended consequences. It's like handing a loaded revolver to a chimpanzee. The outcome will be, as A. Peasant puts it, "regrettable".

    "So far, at least 26 different mRNA shots are on the way from Moderna, in addition to their three types of Covid jabs. The shots in development range from two for HIV to one ‘personalized cancer vaccine.’"
    HIV Now Sets the Pace in the Bogus-vaxx Race

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    Replies
    1. frightening to think of how many will accept these jabs. Now and in the future

      Delete
  6. Hello penny, I like your website and i'm reading your great articles, but lately all about vaccine and pandemic. We are really tired all of that. I don't want to hear about covid any more since all lies. could you please change the topics and write more about politics and future of world. that would be great. But please no more about how many people died from covid/vaccine ....etc . thank you.

    ReplyDelete
    Replies
    1. DISCLAIMER:

      The author writes for this blog in a private capacity which is unrepresentative of anyone or any organization except for her own personal views.

      Nothing written by the author should ever be conflated with the editorial views or official positions of any other media outlet or institution.

      Sometimes this author consults with her husband to solidify thoughts and ideas or to get input regarding military equipment and the like as well. And that's all there is to it!

      Delete
  7. LOL!! Yes, indeed, Penny. Please write about something else. We only have some small cabal of evil busy destroying humanity, but please write about something else. And, oh by the way, you do this for free, right??!! Good grief! LOL!!

    P.S., love the "we are really tired of all that." Is that the royal "we" because you don't speak for me!

    ReplyDelete
    Replies
    1. Hi Gwen:

      Can't make everyone happy all the time eh?

      "We only have some small cabal of evil busy destroying humanity, but please write about something else."

      Yup!

      "And, oh by the way, you do this for free, right??!! "

      Yes, again.

      Thanks :)


      Delete

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